Localization of Erythropoietin and Erythropoietin-Receptor in Postimplantation Mouse Embryos. (erythropoietin/erythropoietin receptor/universal morphogen/neurogenesis/mouse embryo)

The human erythropoietin receptor gene rescues erythropoiesis and developmental defects in the erythropoietin receptor null mouse.

Erythropoietin and its receptor are required for definitive erythropoiesis and maturation of erythroid progenitor cells. Mice lacking the erythropoietin receptor exhibit severe anemia and die at about embryonic day 13.5. This phenotype can be rescued by the human erythropoietin receptor transgene. Animals expressing only the human erythropoietin receptor survived through adulthood with normal h...

Erythropoietin is an essential growth factor that promotes survival, proliferation, and differentiation of mammalian erythroid progenitor cells. Erythropoietin−/− and erythropoietin receptor−/− mouse embryos

Erythropoietin (EPO) is best known as an essential growth factor that regulates erythrocyte production in mammals (Krantz, 1991). Through specific binding to its cognate receptor, EPOR (D’Andrea et al., 1989), EPO triggers a chain of intracellular signaling events which depend on activation of Jak2 tyrosine kinase (Witthuhn et al., 1993). In addition to erythropoiesis, EPO has been found to be ...

Expression of erythropoietin and erythropoietin receptor in peritoneal endometriosis.

BACKGROUND Recent studies have indicated new physiological roles for erythropoietin (Epo) unrelated to erythropoiesis. We previously demonstrated that the Epo concentrations in peritoneal fluid from patients with stage I endometriosis were significantly higher than those with stages II, III and IV of the disease. Therefore, we hypothesized that Epo may play a role in the pathogenesis of endomet...

Development of Radiolabeled Recombinant Erythropoietin for Receptor Studies

Erythropoietin and erythropoietin receptor expression in human cancer.

Erythropoietin (EPO) stimulates the growth of erythroblasts in the bone marrow (C. Lacombe and P. Mayeux, NEPHROL: DIAL: TRANSPLANT:, 14 (SUPPL: 2): 22-28, 1999). We report basal and hypoxia-stimulated expression of EPO and its receptor, EPOR, in human breast cancer cells, and we demonstrate EPO-stimulated tyrosine phosphorylation and the proliferation of these cells in vitro. In 50 clinical sp...